Discovering, design, and application of novel insecticide proteins;
Host-pathogen interactions between B. thuringiensis and its nematode target;
Phage diversity, genomics, and Phage therapy in agriculture production.
2004/09 - 2009/06，Ph.D. of Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China (Advisor: Professor Ming Sun)
2000/09 - 2004/06, BA in Biotechnology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
2018/11 - to date, Professor in College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
2017/06 - 2017/12, Visiting Assistant professor in College of Agriculture and Life Sciences, University of Cornell, Ithaca, USA (Working in Helmann Lab with John Helmann, PhD)
2013/01 - 2018/10, Assistant professor in College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
2009/12 - 2010/02, Visiting fellow in School of Life Sciences, University of Sussex, Brighton, UK (Working in Bt Lab with Neil Crickmore, PhD)
2009/07 - 2012/12, Lecturer in College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
1. Zheng Z, Zhang Y, Liu Z, Dong Z, Xie C, Bravo A, Soberón M, Mahillon J, Sun M*, Peng DH*. The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments. ISME J. 2020. doi: 10.1038/s41396-020-0623-5. (Co-corresponding)
2. Shi J, Peng DH*, Zhang F, Ruan L, Sun M*. (2020) The Caenorhabditis elegans CUB-like-domain containing protein RBT-1 functions as a receptor for Bacillus thuringiensis Cry6Aa toxin. PLoS Pathog, 16(5): e1008501. (Co-corresponding)
3. Wan LT, Lin J, Du HW, Zhang YL, Bravo A, Soberón M, Sun M, Peng DH*. Bacillus thuringiensis targets the host intestinal epithelial junctions for successful infection of Caenorhabditis elegans. Environ Microbiol, 2019, 21(3):1086-1098. (Cover story)
4. Peng DH, Luo XX, Zhang N, Guo SX, Zheng JS, Chen L, Sun M*. Small RNA-mediated Cry toxin silencing allows Bacillus thuringiensis to evade Caenorhabditis elegans avoidance behavioral defenses. Nucleic Acids Res, 2018, 46(1):159-173.
5. Peng DH, Lin J, Huang Q, Zheng W, Liu GQ, Zheng J, Zhu L, Sun M*. A novel metalloproteinase virulence factor is involved in B. thuringiensis pathogenesis in nematodes and insects. Environ Microbiol, 2016, 8(3):846-862.
6. Peng DH, Wang FS, Li NS, Zhang ZY, Song R. Zhu ZM, Ruan LF, Sun M*. Single cysteine substitution in Bacillus thuringiensis Cry7Ba1 improves the crystal solubility and produces toxicity to Plutella xylostella larvae. Environ Microbiol, 2011, 13:2820-2831.
7. Peng DH, Qiu DW, Ruan LF, Zhou CF, Sun M*. Protein elicitor PemG1 from Magnaporthe grisea induces SAR in plants through the salicylic acid and Ca2+-related signaling pathways. Mol Plant Microbe Interact, 2011, 24:1239-1246.
8. Peng DH, Chai LJ, Wang FS, Zhang FJ, Ruan LF, Sun M*. Synergistic activity between Bacillus thuringiensis Cry6Aa and Cry55Aa toxins against Meloidogyne incognita. Microb Biotechnol, 2011, 4(6):794-798.
9. Peng DH, Chen SW, Ruan LF, Li L, Yu ZN, Sun M*. Safety assessment of transgenic Bacillus thuringiensis with VIP insecticidal protein gene by feeding studies. Food Chem Toxicol, 2007, 45, 1179-1185.