金沙国际电玩城

Professor

English - FACULTY - Molecular Biology - Professor - 正文

Ming SUN

来源: 责任编辑:陈华夏 发布:2020-05-28 点击量:


 

 Professor

Tel: +86-27-87283455

E-mail: m98sun@mail.hzau.edu.cn

MajorMicrobial pesticides

 

 Education 

1984.09-1988.07  Wuhan University, Microbiology BS

1988.09-1991.06  Huazhong Agricultural University, Microbiology MsD

1992.09-1995.12  Huazhong Agricultural University, Microbiology PhD

 Working and Research Experiences 

1991.07-now      Huazhong Agricultural University

1994. 05-1994.11  The Ohio State University, visiting scholar

1997.06-1997.09   University of Waterloo, UNISCO-ASM visiting scholar

1997.10-1998.10   Institute of Molecular Agrobiology, visiting scholar

2002.07-2003.01   Cornell University, senior visiting scholar

2004.05-2004.11   The University of Hong Kong, Croucher visiting scholar

 Research 

Research field: Research and development of microbial pesticides based on Bacillus thuringiensis, as well as the biocontrol of plant parasitic nematodes and the study of its biology.

Research funding:

1.        Diversity of RNA regulation in Bacillus thuringiensis, NSFC, 2017/01-2020/12.

2.        Screening and directional improvement of efficient broad-spectrum insecticidal microorganisms, National key R & D Plan Project, 2017/07-2020/12.

3.        The function and action mode of type II toxin-antitoxin system of Bacillus thuringiensis during its infecting hostsNSFC, 2020/01-2023/12.

Selected publications:

1.        Shi J, Peng D, Zhang F, Ruan L, Sun M (2020) The Caenorhabditis elegans CUB-like-domain containing protein RBT-1 functions as a receptor for Bacillus thuringiensis Cry6Aa toxin. PLoS Pathog. 16(5):e1008501.

2.        Xin B, Liu H, Zheng J, Xie C, Gao Y, Dai D, Peng D, Ruan L, Chen H, Sun M (2020) In Silico analysis highlights the diversity and novelty of circular bacteriocins in sequenced microbial genomes. mSystems. 5(3):e00047-20.

3.        Zheng Z, Zhang Y, Liu Z, Dong Z, Xie C, Bravo A, Soberón M, Mahillon J, Sun M, Peng D. (2020) The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments. ISME J. 14(6):1479-1493. 

4.        Deng Y, Chen H, Li C, Xu J, Qi Q, Xu Y, Zhu Y, Zheng J, Peng D, Ruan L, Sun M. (2019) Endophyte Bacillus subtilis evade plant defense by producing lantibiotic subtilomycin to mask self-produced flagellin. Commun Biol, 2:368.

5.        Sajid M, Geng C, Li M, Wang Y, Liu H, Zheng J, Peng D, Sun M. (2018) Whole-Genome Analysis of Bacillus thuringiensis Revealing Partial Genes as a Source of Novel Cry Toxins. Appl Environ Microbiol, 84(14). doi: 10.1128/AEM.00277-18.

6.        Peng D, Luo X, Zhang N, Guo S, Zheng J, Chen L, Sun M. (2018) Small RNA-mediated Cry toxin silencing allows Bacillus thuringiensis to evade Caenorhabditis elegans avoidance behavioral defenses. Nucleic Acids Res, 46(1):159-173.

7.        Geng C, Liu Y, Li M, Tang Z, Muhammad S, Zheng J, Wan D, Peng D, Ruan L, Sun M. (2018) Dissimilar Crystal Proteins Cry5Ca1 and Cry5Da1 Synergistically Act against Meloidogyne incognita and Delay Cry5Ba-Based Nematode Resistance. Appl Environ Microbiol, 83(18). doi: 10.1128/AEM.03505-16.

8.        Zheng J, Gao Q, Liu L, Liu H, Wang Y, Peng D, Ruan L, Raymond B, Sun M. (2018) Comparative Genomics of Bacillus thuringiensis Reveals a Path to Specialized Exploitation of Multiple Invertebrate Hosts. mBio, 8(4). doi: 10.1128/mBio.00822-17.

9.        Du C, Cao S, Shi X, Nie X, Zheng J, Deng Y, Ruan L, Peng D, Sun M. (2017) Genetic and biochemical characterization of a gene operon for trans-aconitic acid, a novel nematicide from Bacillus thuringiensis. J Biol Chem, 292(8):3517-3530.

10.    Zheng J, Peng D, Chen L, Liu H, Chen F, Xu M, Ju S, Ruan L, Sun M. (2016) The Ditylenchus destructor genome provides new insights into the evolution of plant parasitic nematodes. Proc Biol Sci, 283(1835). pii: 20160942.

11.    Zhang F, Peng D, Cheng C, Zhou W, Ju S, Wan D, Yu Z, Shi J, Deng Y, Wang F, Ye X, Hu Z, Lin J, Ruan L, Sun M. (2016) Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1). PLoS Pathog, 12(1):e1005389.

12.    Peng DH, Lin J, Huang Q, Zheng W, Liu GQ, Zheng J, Zhu L, Sun M, (2016) A novel metalloproteinase virulence factor is involved in B. thuringiensis pathogenesis in nematodes and insects. Environ Microbiol, 18(3):846-862.

13.    Ju S, Lin J, Zheng J, Wang S, Zhou H, Sun M. (2016) Alcaligenes faecalis ZD02, a novel nematicidal bacterium with an extracellular serine protease virulence factor. Appl Environ Microbiol, 82(7):2112-2120.

14.    Ruan L, Crickmore N, Peng D, Sun M. (2015) Are nematodes a missing link in the confounded ecology of the entomopathogen Bacillus thuringiensis? Trends Microbiol, 23(6):341-346.

15.    Ruan L, Wang H, Cai G, Peng D, Zhou H, Zheng J, Zhu L, Wang X, Yu H, Li S, Geng C, Sun M. (2015) A two domain protein triggers heat shock pathway and necrosis pathway both in model plant and nematode. Environ Microbiol, 17(11):4547-4565.

16.    Xin B, Zheng J, Xu Z, Li C, Ruan L, Peng D, Sun M (2015) Three novel lantibiotics ticin A1, A3, and A4 have extremely stable properties and are promising food bio-preservatives. Appl Environ Microbiol, 81(20):6964-7220.

17.    Xin B, Zheng J, Xu Z, Song X, Ruan L, Peng D, Sun M. (2015) The Bacillus cereus group is an excellent reservoir of novel Lanthipeptides. Appl Environ Microbiol, 81(5):1765-1774.

18.    Zheng J, Gänzle MG, Lin XB, Ruan L, Sun M. (2015) Diversity and dynamics of bacteriocins from human microbiome. Environ Microbiol, 17(6):2133-2143.

19.    Deng Y, Li CZ, Zhu YG, Wang PX, Qi QD, Fu JJ, Peng DH, Ruan LF, Sun M. (2014) ApnI, a transmembrane protein responsible for subtilomycin immunity, unveils a novel model for lantibiotic immunity. Appl Environ Microbiol, 80(20):6303-6315.

20.    Luo X, Chen L, Huang Q, Zheng J, Zhou WPeng DRuan L, Sun M. (2013) Bacillus thuringiensis metalloproteinase Bmp1 functions as a nematicidal virulence factor. Appl Environ Microbiol, 79(2):460-468.

21.    Wang P, Liu Y, Zhang C, Zhu Y, Deng YGuo SPeng D, Ruan L, Sun M. (2013)The resolution and regeneration of a cointegrate plasmid reveals a model for plasmid evolution mediated by conjugation and oriT site-specific recombination. Environmental Microbiology, 15(12):3305-3318.

22.    Zheng J, Peng D, Song X , Ruan L, Mahillon JSun M. (2013) Differentiation of Bacillus thuringiensis, B. cereus, and B. thuringiensis on the basis of the csaB gene reflects host source. Appl Environ Microbiol, 79(12):3860-3863.

23.    Wang F, Liu Y, Zhang F, Chai L, Ruan L, Peng D, Sun M. (2012) Improvement of crystal solubility and increasing toxicity against Caenorhabditis elegans by Asparagine substitution in Block 3 of Bacillus thuringiensis crystal protein Cry5Ba. Appl Environ Microbiol, 78(20):7197-7204.

24.    Ye W, Zhu L, Liu Y, Crickmore N, Peng D, Ruan L, Sun M. (2012) Mining new crystalprotein genes from Bacillus thuringiensis on the basis of mixed plasmid-enriched genome sequencing and a computational pipeline. Appl Environ Microbiol, 78(14):4795-4801.

25.    Luo Y, Ruan L, Zhao C, Wang C, Peng D, Sun M. (2011) Validation of the intact Zwittermicin A biosynthetic gene cluster and discovery of a complementary resistance mechanism in Bacillus thuringiensis. Antimicrob Agents Chemother, 55(9):4161-4169.

26.    Peng D, Qiu D, Ruan L, Zhou C, Sun M. (2011) Protein elicitor PemG1 from Magnaporthe grisea induces SAR in plants through the salicylic acid and Ca2+-related signaling pathways. Mol Plant Microbe Interact, 24(10):1239-1246.

27.    Peng D, Wang F, Li N, Zhang Z, Song R. Zhu Z, Ruan L, Sun M. (2011) Single cysteine substitution in Bacillus thuringiensis Cry7Ba1 improves the crystal solubility and produces toxicity to Plutella xylostella larvae. Environ Microbiol, 13(10):2820-2831.

28.    Liu X, Ruan L, Hu Z, Peng D, Cao S, Zheng J, Liu Y, Yu Z, Sun M. (2010) Genome wide screening revealed the genetic determinants of a antibiotic insecticide in Bacillus thuringiensis. J Biol Chem, 285: 39191-39200.

29.    Fang S, Wang L, Guo W, Zhang X, Peng D, Luo C, Yu Z, Sun M. (2009) Bacillus thuringiensis Bel protein synergizes the toxicity of Cry1Ac protein to Helicoverpa armigera larvae by degrading insect intestinal mucin. Appl Environ Microbiol, 75: 5237–5243.

30.    Guo S, Liu M, Peng D, Ji S, Wang P,Yu Z, Sun M. (2008) New strategy for isolating novel nematicidal crystal protein genes from Bacillus thuringiensis strain YBT-1518. Appl Environ Microbiol, 74: 6997-7001.

31.    Sun M, Gene Engineering (2nd edition), 2013, Beijing: Higher Education Press.

Chief editor of journal “Biotic Resources”.

(see other publicationshttps://www.ncbi.nlm.nih.gov/sites/myncbi/1rcLFq9J3NKAY/bibliography/49497510/public/?sort=date&direction=descending)


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